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Biostatistics and Bioinformatics Shared Resource

Ralph D'Agostino Jr., Ph.D.


Department of Biostatistical Sciences
Director Biostatistics Core, Comprehensive Cancer Center
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
Tel: 336-716-9410 or 336-716–9011
Fax:  336-716–4128


Bowdoin College, AB, Mathematics
Harvard University, AM, Statistics
Harvard University, PhD, Statistics

Research Topics

  • Observational Study Methodology
  • Propensity Score methods
  • Missing Data Methods
  • Measurement Error models
  • Cardio-Oncology
  • Lung Cancer
  • Insulin Resistance
  • Metabolic Syndrome  

Current Research

Dr. D'Agostino has been the Director of the Biostatistics Core since 2004.  He is a Professor in the department of Biostatistical Sciences and Fellow of the American Statistical Association.  He has over 250 peer reviewed publications and has served as the PI, Co-PI and the lead/statistician on numerous federally funded contracts, grants or subcontracts.  He has worked on developing methods for using propensity score techniques in clinical research.  His 1998 Statistics in Medicine paper describing propensity score methods in clinical research has been referenced more than 2500 time.   He has also worked on methods for estimating propensity scores in the presence of missing data.  In addition, he has worked on using propensity score methods to derive data sets that can be used for clinical research when it was not possible to randomize patients.   He is also currently working on research methods to model the probability of long term cardiovascular complications for patients receiving chemotherapy.  

Selected Publications

  1. D’Agostino RB JrPropensity score methods for bias reduction for the comparison of a treatment to a non-randomized control group.  Statistics in Medicine. 1998;17:2265-2281. PMID: 9802183.
  2. D’Agostino RB Jr, Rubin DB.  Estimating and using propensity scores with partially missing data. Journal of the American Statistical Association, 2000; 95(451): 749-759.
  3. D’Agostino RB Jr, D’Agostino RB Sr.  Estimating treatment effects using observational data. JAMA 2007 297(3):314-316. PMID: 17227985.
  4. Eckman DM, Stacey RB, Rowe R, D'Agostino R Jr, Kock ND, Sane DC, Torti FM, Yeboah J, Workman S, Lane KS, Hundley WG. Weekly doxorubicin increases coronary arteriolar wall and adventitial thickness. PLoS One. 2013;8(2):e57554. doi: 10.1371/journal.pone.0057554. Epub 2013 Feb 21.PMID:23437398.
  5. Drafts BC, Twomley KM, D'Agostino R Jr, Lawrence J, Avis N, Ellis LR, Thohan V, Jordan J, Melin SA, Torti FM, Little WC, Hamilton CA, Hundley WG. Low to Moderate Dose Anthracycline-Based Chemotherapy Is Associated With Early Noninvasive Imaging Evidence of Subclinical Cardiovascular Disease. JACC Cardiovasc Imaging. 2013 Aug;6(8):877-85. doi: 10.1016/j.jcmg.2012.11.017. Epub 2013 May 1.PMID:23643285.
  6. Wang W, Deng Z, Hatcher H, Miller LD, Di X, Tesfay L, Sui G, D'Agostino RB Jr, Torti FM, Torti SV. IRP2 regulates breast tumor growth. Cancer Res. 2014 Jan 15;74(2):497-507. doi: 10.1158/0008-5472.CAN-13-1224. Epub 2013 Nov 27.PMID:24285726 .
  7. Hassan S, Karpova Y, Flores A, D'Agostino R Jr, Kulik G. Surgical stress delays prostate involution in mice.  PLoS One. 2013 Nov 6;8(11):e78175. doi: 0.1371/journal.pone.0078175. PMID: 24223137.
  8. Gralnek IM, Siersema PD, Halpern Z, Segol O, Melhem A, Suissa A, Santo E, Sloyer A, Fenster J, Moons LM, Dik VK, D'Agostino RB Jr, Rex DK. Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial. Lancet Oncol. 2014 Mar;15(3):353-60. doi: 10.1016/S1470-2045(14)70020-8. Epub 2014 Feb 20.PMID:24560453.
  9. Ghosh S, Ucer KB, D'Agostino R Jr, Grant K, Sirintrapun J, Thomas MJ, Hantgan R, Bharadwaj M, Gmeiner WH. Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity. Nanomedicine. 2014 Feb;10(2):451-61. doi: 10.1016/j.nano.2013.07.019. Epub 2013 Aug 27. PMID: 23988714.
  10. Yosipovitch G, Mills KC, Nattkemper LA, Feneran A, Liang TH, Lowenthal BM, Pearce DJ, Williford PM, Sangueza OP, D'Agostino RB Jr. Association of Pain and Itch With Depth of Invasion and Inflammatory Cell Constitution in Skin Cancer: Results of a Large Clinicopathologic Study. JAMA Dermatol. 2014 Jul 23. doi: 10.1001/jamadermatol.2014.895. [Epub ahead of print] PMID: 25055194. 
  11. Jordan JH, D'Agostino RB Jr, Hamilton CA, Vasu S, Hall ME, Kitzman DW, Thohan V, Lawrence JA, Ellis LR, Lash TL, Hundley WG Longitudinal Assessment of Concurrent Changes in Left Ventricular Ejection Fraction and Left Ventricular Myocardial Tissue Characteristics After Administration of Cardiotoxic Chemotherapies Using T1-Weighted and T2-Weighted Cardiovascular Magnetic Resonance. Circ Cardiovasc Imaging. 2014 Oct 1. pii: CIRCIMAGING.114.002217. [Epub ahead of print] PMID: 25273568.
  12. Mays AC, Moustafa F, Worley M, Waltonen JD, D'Agostino R Jr. A Model for Predicting Gastrostomy Tube Placement in Patients Undergoing Surgery for Upper Aerodigestive Tract Lesions. JAMA Otolaryngol Head Neck Surg. 2014 Oct 9. doi: 10.1001/jamaoto.2014.2360. [Epub ahead of print] PMID: 25321077.
  13. Alistar A, Chou JW, Nagalla S, Black MA, D'Agostino R Jr, Miller LD Dual roles for immune metagenes in breast cancer prognosis and therapy prediction. Genome Med. 2014 Oct 28;6(10):80. eCollection 2014. PMID: 25419236.
  14. Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG. Chronic Statin Administration May Attenuate Early Anthracycline-Associated Declines in Left Ventricular Ejection Function. Can J Cardiol. 2014 Nov 26. pii: S0828-282X(14)01609-2. doi: 10.1016/j.cjca.2014.11.020. [Epub ahead of print] PMID: 25662284.

Quick Reference

Biostatistics and Bioinformatics Shared Resource
Executive Director
Ralph D'Agostino Jr., PhD


Xiaobo Zhou, PhD

Senior Biostatisticians
Janet Tooze, PhD

Doug Case, PhD

Fang-Chi Hsu, PhD

Senior Bioinformaticians
Carl Langefeld, PhD

Guangxu Jin, PhD

Jing Su, PhD

Scott Isom, MS

Greg Russell, MS

Beverly Levine, PhD

Jeff Chou, PhD

Liang Lui, PhD

Dave McWilliams, PhD

Jian Zhang, PhD

Tina Martin, BSBA


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