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Crystallography and Computational Biosciences


The Crystallography and Computational Biosciences Shared Resource serves as a portal for access to state-of-the-art X-ray crystallographic equipment, technical support, high-performance computing, and scientific consultation for Cancer Center researchers. The Shared Resource exists to meet the growing needs for structure determination and computational analysis of protein and DNA/RNA structure, function and dynamics for a diverse array of projects ranging from basic science questions to drug design.


Macromolecular X-ray crystallography is an experimental method to determine the three-dimensional structure of proteins, DNA/RNA, their complexes, and the complexes of a variety of ligands including cofactors, substrates, drug candidates, etc. The Computational Bioscience portion of resource provides access to cutting-edge modeling and simulation methods. The information from these complementary approaches can be used to develop novel therapies, as it is essential for assessing and exploiting the biological function of the target protein. The CCB resource provides support for ongoing projects and the development of new projects through the collection of preliminary data for funding applications.



      • Wake Forest Biotech Place, Center for Structural Biology, Department of Biochemistry, Rooms 2W-020 and 2W-022
      • Olin Hall, Department of Physics

      2016 Research Shared Resource Symposium Presentation

        Quick Reference

        Cystallography and Computational Biosciences
        Dr. W. Todd Lowther

        Dr. Tom Hollis

        Dr. Fred Salsbury

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