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General Internal Medicine Research

The research interests of physicians and faculty of the Section of General Internal Medicine are diverse.  Some of the funding sources for this research include: the National Institutes of Health (NIH); the American Cancer Society (ACS); and the state of North Carolina.

The goal of FOCUS is to examine a transfusion strategy for those patients with cardiovascular disease who are having surgery to repair a hip fracture.  Specifically, the study wants to determine if a more aggressive transfusion strategy in these patients is associated with improved functional recovery and decreased risk of adverse postoperative outcomes such as acute myocardial infarction or death.

David P. Miller, Jr., MD, MS, FACP, conducts educational and health services research. His past projects have included the development of a multi-year obesity prevention and management curriculum ( and the creation and implementation of a comprehensive substance abuse screening and management curriculum for primary care residencies (

Dr. Miller’s health services research focuses on the use of mobile health (mHealth) and other technologies to improve the delivery of primary care.  His studies have included a systematic review of clinic-based computer-assisted instruction, randomized controlled trials of computer and web-based patient education programs/decision aids, and pilot studies with mobile devices in socioeconomically disadvantaged patient populations.  He is currently the PI of a National Cancer Institute funded study (1R01CA178941) testing the ability of a multilevel clinic-based mHealth intervention to improve colorectal cancer screening rates, particularly among low literacy patients.  Dr. Miller also serves as co-investigator of a study examining low-income older adults’ ability to use information technology applications for electronic personal health information management.(1R01HS021679).

David Mount, MD, has been awarded a minority supplement from the NIH-sponsored Look AHEAD and ACCORD clinical trials.

Carolyn F. Pedley, MD, continues her work with the NIH-sponsored ACCORD trial. Action to Control Cardiovascular Risk in Diabetes trial (ACCORD), and is the PI in another NIH-sponsored study,  Systolic Blood Pressure Intervention Trial (SPRINT), which will evaluate the benefits of tight blood pressure control in patients with high risk factors for cardiovascular events.  She is also the COPI of Care Now, a grant funded by Medicaid to improve clinical outcomes in high risk Medicaid patients utilizing health navigators at Wake Forest University Downtown Health Plaza.  She is coinvestigator in the HELP PD trial, which is a NIH funded study to prevent diabetes in high risk individuals through a program of weight loss, through diet and exercise, utilizing health advisors. She is PI in the TECOS trial, a multicentered trial sponsored by Merck and managed by Duke Clinical Research Institute, to evaluate the cardiac benefits of sitagliptin in high risk diabetics.


Last Updated: 06-17-2016
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