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Book Chapters

Cristina M. Furdui and Karen S. Anderson, Detection of Novel Enzyme Intermediates, Comprehensive Natural Products Chemistry II, vol. 8, pg.663, Elsevier, 2010.

Journal Articles 


1. Parsonage D., Nelson K.J., Ferrer-Sueta G., Alley S.G., Karplus P.A., Furdui C.M., Poole L.B.. (2015) "Dissecting Peroxiredoxin Catalysis: Separating Binding, Peroxidation, and Resolution for a Bacterial AhpC" Biochemistry, Jan 29. [Epub ahead of print]
2.Mims J, Bansal N , Bharadwaj M.S., Chen X., Molina A.J., Tsang A.W., Furdui C.M. (2015) “Energy metabolism in a matched .model of radiation resistance for head and neck squamous cell cancer.  Radiat Res. Mar;183(3):291-304. doi: 10.1667/RR13828.1. Epub 2015 Mar 4. 
3. Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM. (2015) “Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors.” Epigenetics. Jun 3;10(6):545-61. doi:10.1080/15592294.2015.1048953. 

4. Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN. (2015) “Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells.” Int J Nanomedicine. Jun 11;10:3937-53. doi: 10.2147/IJN.S80349. eCollection 2015


1. Patel A.L., Chen X., Wood S.T., Stuart E.S., Arcaro K.F., Molina D.P., Petrovic S., Furdui C.M.*, Tsang A.W.. (2014) "Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development" BMC Microbiol. 14(1):277. * co-correpsonding author 

2. Devarie Baez N.O., Reisz J.A., Furdui C.M., (2014) "Mass spectrometry in studies of protein thiol chemistry and signaling: Opportunities and caveats" Free Radic Biol Med. 2014 Sep 28. pii: S0891-5849(14)00435-3. doi: 10.1016/j.freeradbiomed.2014.09.016.

3. Poole T.H., Reisz J.A., Zhao W., Poole L.B., Furdui C.M., King S.B. (2014) “Strained Cycloalkynes as New Protein Sulfenic Acid Traps” J Am Chem Soc. 136(17):6167-70. doi: 10.1021/ja500364r.

4. Furdui C.M., (2014) “Ionizing Radiation: Mechanisms and Therapeutics” Antioxid Redox Signal. 21(2):218-20. doi: 10.1089/ars.2014.5935.

5. Bansal N., Mims J., Kuremsky J.G., Olex A.L., Zhao W., Yin L., Wani R., Qian J., Center B., Marrs G.S., Porosnicu M., Fetrow J.S., Tsang A.W., Furdui C.M. (2014) “Broad Phenotypic Changes Associated with Gain of Radiation Resistance in HNSCC.” Antioxid Redox Signal. 21(2):221-36. doi: 10.1089/ars.2013.5690.

6. Reisz J.A., Bansal N., Qian J., Zhao W., Furdui C.M. (2014) “Effects of ionizing radiation on biological molecules: Mechanisms of damage and emerging methods of detection.” Antioxid Redox Signal. 21(2):260-92. doi: 10.1089/ars.2013.5489.


1. Furdui C.M., Poole L.B. (2013) “Chemical approaches to detect and analyze protein sulfenic acids.” Mass Spectrom Rev. 33(2):126-46. doi: 10.1002/mas.21384. 

2. Reisz J.A., Bechtold E., King S.B., Poole L.B., and Furdui C.M. (2013) “Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.” FEBS J., 280(23):6150-61. doi: 10.1111/febs.12535. 

3. Haynes A.C., Qian J., Reisz J.A., Furdui C.M.*, Lowther W.T. (2013) “Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation.” J Biol Chem. 288(41):29714-23. doi: 10.1074/jbc.M113.473470.
*co-corresponding author.

4. Lee Y., Mehra-Chaudhary R., Furdui C.M., Beamer L.J. (2013) “Identification of an essential active-site residue in the α-d-phosphohexomutase enzyme superfamily.” FEBS J. 280(11):2622-32.


1. Lang BS, Gorren AC, Oberdorfer G, Wenzl MV, Furdui CM, Poole LB, Mayer B, Gruber K. (2012) Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. J Biol Chem. Epub.

2. Lee Y, Mick J, Furdui CM, Beamer LJ. (2012) A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family. PLoS One. 7(6):e38114.

3. Feng X., Zhang T., Xu Z., Choi S.J., Qian J., Furdui C.M., Register T.C., Delbono O. (2012) Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp. Gerontol. 47(8):601-7.

4. Qian J., Wani R., Klomsiri C., Poole L.B., Tsang A.W., Furdui C.M. (2012) A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes. Chem. Commun. (Camb). 48(34):4091-3.


1. Glazer P.M., et al. (NCI Workshop Participants – Furdui C.M.) (2011). Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010. Radiat. Res. 176(3):e0016-21.

2. Wani R., Tsang A.W., Furdui C.M. (2011) Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle. Cell Cycle. Oct 1;10(19).

3. Qian J., Klomsiri C., Wright M.W., King S.B., Tsang A.W., Poole L.B., Furdui C.M. (2011) “Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.” Chem. Commun. (Camb), 47(32):9203-5.

4. Wani R., Qian J., Yin L., Bechtold E., King S.B., Poole L.B., Paek E., Tsang A.W. and Furdui C.M. (2011) “Isoform-specific Regulation of Akt by PDGF-induced Reactive Oxygen Species” Proc. Natl. Acad. Sci. U.S.A., 108(26):10550-5.

5. Codina J., Opyd T.S., Powell Z.B., Furdui C.M., Petrovic S., Penn R.B., Dubose T.D. Jr. (2011) “pH-dependent regulation of the {alpha}-subunit of H+,K+-ATPase (HK{alpha}2)” Am. J. Physiol. Renal Physiol., 301(3):F536-43.

1999 - 2010

1. Roberts A., Furdui C.M., Anderson K.S. (2010) “Observation of a chemically labile, noncovalent enzyme intermediate in the reaction of metal-dependent Aquifex pyrophilus KDO8PS by time-resolved mass spectrometry” Rapid Commun. Mass Spectrom. 24(13):1919-24.

2. Schramm A.M., Karr D., Mehra-Chaudhary R., Van Doren S.R., Furdui C.M., Beamer L.J. (2010) “Breaking the covalent connection: Chain connectivity and the catalytic reaction of PMM/PGM” Protein Sci. 19(6):1235-42.

3. Klomsiri C., Nelson K.J., Bechtold E., Soito L., Johnson L.C., Lowther W.T., Ryu S.E., King S.B., Furdui C.M., Poole L.B. (2010) “Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins” Methods Enzymol., 473:77-94.

4. Bechtold E., Reisz J.A., Klomsiri C., Tsang A.W., Wright M.W., Poole L.B., Furdui C.M., King S.B. (2010) “Water-Soluble Triarylphosphines as Biomarkers for Protein S-Nitrosation” ACS Chem. Biol., 5(4):405-14. PMCID: PMC2863053.

5. Wallen J.R., Mallett T.C., Boles W., Parsonage D., Furdui C.M., Karplus P.A., Claiborne A. (2009) “Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: Implications for flavin-linked sulfur trafficking.” Biochemistry, 48(40):9650-67.

6. Lew E.D., Furdui C.M., Anderson K.S. and Schlessinger J. (2009) “The precise sequence of FGF-receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations” Science Signaling, 2 (58), ra6.

7. Jäntschi, L., Bolboaca, S.D. and Furdui, C.M. (2009) “Characteristic and counting polynomials: modelling nonane isomers properties”, Molecular Simulation, 35:3,220-227.

8. Jönsson T.J., Tsang A.W., Lowther W.T., Furdui C.M. (2008) “Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin.” J. Biol. Chem., 283(34):22890-4.

9. Schramm A.M., Mehra-Chaudhary R., Furdui C.M.*, Beamer L.J. (2008) “Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Biochemistry, 47(35):9154-62.
*co-corresponding author

10. Poole, L.B., Klomsiri, C., Knaggs, S.A., Furdui, C.M., Nelson, K.J., Thomas, M.J., Fetrow, J.S., Daniel, LW, and King, S.B. (2007) “Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins”, Bioconjug. Chem., 18(6):2004-17.

11. Furdui, C.M., Lew, E. D., Schlessinger, J. and Anderson, K.S. (2006) “Temporal resolution of fibroblast growth factor receptor kinase autophosphorylation”, Mol. Cell, 21(5):711-7.

12. Mansoorabadi S.O., Seravalli J., Furdui C.M., Krymov V., Gerfen G.J., Begley T.P., Melnick J., Ragsdale S.W., Reed G.H., (2006) “EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate:ferredoxin oxidoreductase”, Biochemistry, 45(23):7122-7131.

13. Furdui, C.M., Sau, A., Baasov, T., Woodard, R.W. and Anderson, K.S. (2005) “The use of (E)- and (Z)-[3F]-phosphoenolpyruvate as mechanistic probes reveals significant differences between the active sites of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-2-heptulosonate-7-phosphate synthase”, Biochemistry, 44(19):7326-35.

14. Li, Z., Sau, A., Furdui, C.M. and Anderson, K.S. (2005) “Probing the role of tightly bound phosphoenolpyruvate in E. coli 3-deoxi-D-manno-octulosonate 8-phosphate (KDO8P) synthase catalysis using quantitative time-resolved electrospray ionization mass spectrometry in the millisecond time range”, Anal. Biochem., 343(1):35-47.

15. Shulami, S., Furdui, C.M., Adir, N., Shoham, Y., Anderson, K.S. and Baasov, T. (2004) “A reciprocal single mutation affects the metal requirement of KDO8P synthases from Aquifex pyrophilus and Escherichia coli”, J. Biol. Chem., 279(43):45110-20.

16. Furdui, C.M., Zhou, L., Woodard, R., and Anderson, K.S. (2004) “Insights into the mechansim of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP Synthase) (Phe) from E. coli using a transient kinetic analysis”, J. Biol. Chem., 279(44):45618-25.

17. Furdui C.M., Ragsdale S.W. (2002). “The roles of coenzyme A in the pyruvate:ferredoxin oxidoreductase reaction mechanism: rate enhancement of electron transfer from a radical intermediate to an iron-sulfur cluster”, Biochemistry; 41(31):9921-37.

18. Furdui, C.M., Ragsdale, S.W. (2000), “The role of pyruvate ferredoxin oxidoreductase in pyruvate synthesis during autotrophic growth by the Wood-Ljungdahl pathway”, J. Biol. Chem., 275: 28494-9.

19. Bouchev, V.F., Furdui C.M., Menon, S., Ragsdale, S.W. and McMracken, J. (1999) “ENDOR studies of pyruvate:ferredoxin oxidoreductase reaction intermediates”, JACS 121: 3724-3729.

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Cristina Furdui

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