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Aaron Goldstein, PhD

Aaron Goldstein, PhD, Associate Professor

Aaron Goldstein, PhDDr. Goldstein received a B.S. and Ph.D. degrees in Chemical Engineering at University of California Berkeley and Carnegie Mellon University, respectively, and was a post-doctoral research associate in the Department of Bioengineering at Rice University under the mentorship of Dr. Antonios Mikos. He has been a faculty member in the Department of Chemical Engineering at Virginia Polytechnic Institute and State University since 1999 and a core faculty member of the Virginia Tech/Wake Forest School of Biomedical Engineering and Sciences since its inception in 2003.

SYNOPSIS OF AREA OF INTEREST: Dr. Goldstein's research efforts have focused on the development of in vitro strategies to form materials for the repair of bone and ligament deficits. This work has included the synthesis and processing of biocompatible degradable polymers and the development of bioreactor strategies to stimulate differentiation of mesenchymal progenitor cells.

DETAILED AREA OF INTEREST: His research group has focused on two avenues of research toward the development of engineered bone and ligament tissues: biomaterial processing, and bioreactors.

Biomaterials processing: The ability to use polymers with tunable chemistries and mechanical properties will permit the systematic examination of cell/biomaterial interactions on tissue development. In collaboration with Drs. Scott Guelcher (Vanderbilt University), Abby Whittingon (Virginia Tech), and Sang Jin Lee (WFIRM) he has been preparing complex and spatially graded fiber and foam structures for ligament and bone applications. Recently, in collaboration with Drs. Manny Opara (WFIRM) and Kevin Edgar (Virginia Tech) he has been constructing composite scaffolds with a hydrogel phase for soft tissue applications.

Bioreactors: In conjunction with Drs. George Christ (University of Virginia), Linda Dahlgren (Virginia Tech), and Sang Jin Lee and James Yoo (WFIRM) cyclic stretch and perfusion bioreactor systems are being tested to stimulate differentiation of mesenchymal progenitor cells into ligament- and bone-like tissues, respectively. Concurrently, studies are being conducted to understand how mechanotransductive signaling pathways are modulated by dynamic mechanical stimulus.

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Institute for Regenerative Medicine

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