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Manisha Nautiyal, PhD


Research Scientist
UNC Eshelman School of Pharmacy
University of North Carolina-Chapel Hill



Ph.D., Molecular Medicine and Translational Science Graduate Program, Dec. 2008
Wake Forest University Graduate School of Arts and Sciences

M.S., Organic Chemistry, 1999
H.N.B. Garhwal University, India

B.S., Biology/Chemistry, 1997 
H.N.B. Garhwal University, India

Research Interest:

How metabolism of the branched chain amino acid (BCAA) leucine is involved in regulating leucine signaling.


Islam M, Nautiyal M, Wynn RM, Mobley JA, Chuang DT and Hutson SM. The Branched Chain Amino Acid (BCAA) Metabolon: Interaction of Glutamate Dehydrogenase with the mitochondrial branched chain aminotransferase (BCATm). J Biol Chem. 2010 Jan 1;285(1):265-76. Epub 2009 Oct 26. PMCID: PMC2804173

Nautiyal M, Sweatt AJ, MacKenzie JA, Payne RM, Wilkinson JC, Szucs S, Matalon R, Wallin R and Hutson SM. Neuronal Localization of mitochondrial protein NIPSNAP1 in rat nervous system. (Submitted: European Journal of Neuroscience, Nov. 12th 2009)

Nautiyal M, Islam M, Wajih N, Mobley JA, MacKenzie JA, Payne RM, Wallin R, Hutson S. Identification and characterization of mitochondrial NIPSNAP1. (In preparation)

Nautiyal M, Sweatt AJ, and Hutson SM. Neuronal Localization of the Branched-Chain Amino Acid (BCAA) Metabolon Protein Component, NIPSNAP1, in rat brain. Western NC Chapter of the Society for Neuroscience (WNCSN). Dec 3, 2007. Wake Forest School of Medicine, NC. Poster Presentation.

Nautiyal M, Wajih N, Fujii H, Wallin R, Hutson S. “Identification of NIPSNAP1 as a component of a supramolecular complex of leucine catabolic enzymes.” The FASEB Journal. 2004 March 24;18 (5): A848.

For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.


American Heart Association, Pre-Doctoral Fellowship Nautiyal (PI) Investigating the function(s) of a novel protein, NIPSNAP1, in a complex (metabolon) of mitochondrial metabolic enzymes Role: PI

2005-2006 Molecular Medicine NIH Training Grant

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Molecular Medicine and Translational Science Graduate Program

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